Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm

March 4, 2024

  • Keia Sanderson, Russell Griffin, Nekayla Anderson, Andrew M South, Jonathan R Swanson, Michael Zappitelli, Heidi J Steflik, Marissa J DeFreitas, Jennifer Charlton, David Askenazi; Neonatal Kidney Collaborative (NKC) Research Committee
  • Of 923 participants, 2% had early severe AKI. In the adjusted model, gestational diabetes (adjusted HR (aHR) 5.4, 95% CI 1.1-25.8), non-steroidal anti-inflammatory drugs (NSAIDs) (aHR 3.2, 95% CI 1.0-9.8), and vancomycin (aHR 13.9, 95% CI 2.3-45.1) were associated with early severe AKI. Late severe AKI occurred in 22% of participants. Early severe AKI (aHR 2.5, 95% CI 1.1-5.4), sepsis (aHR 2.5, 95% CI 1.4-4.4), vasopressors (aHR 2.9, 95% CI 1.8-4.6), and diuretics (aHR 2.6, 95% CI 1.9-3.6) were associated with late severe AKI. Participants who had necrotizing enterocolitis or received NSAIDs had longer severe AKI duration.
  • doi: 10.1038/s41390-024-03102-w