Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial

December 29, 2022

Michelle C Starr, Russell Griffin, Katja M Gist, Jeffrey L Segar, Rupesh Raina, Ronnie Guillet, Saudamini Nesargi, Shina Menon, Nekayla Anderson, David J Askenazi, David T Selewski; Neonatal Kidney Collaborative Research Committee. JAMA Netw Open. 2022 Dec 1;5(12):e2248826.

A total of 874 neonates (449 [51.4%] male; mean [SD] BW, 801 [188] g; 187 [21.4%] Hispanic, 676 [77.3%] non-Hispanic, and 11 [1.3%] of unknown ethnicity; 226 [25.9%] Black, 569 [65.1%] White, 51 [5.8%] of other race, and 28 [3.2%] of unknown race) were included in this analysis. Of these 874 neonates, 458 (52.4%) received mechanical ventilation on postnatal day 14, and 291 (33.3%) had severe BPD or had died. Median peak positive FB was 11% (IQR, 4%-20%), occurring on postnatal day 13 (IQR, 9-14). A total of 93 (10.6%) never decreased below their BW.

doi: 10.1001/jamanetworkopen.2022.48826

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Documentation of acute kidney injury at discharge from the neonatal intensive care unit and role of nephrology consultation.

June 8, 2022

Chmielewski J, Chaudhry PM, Harer MW, Menon S, South AM, Chappell A, Griffin R, Askenazi D, Jetton J, Starr MC; Neonatal Kidney Collaborative. J Perinatol. 2022 Jul;42(7):930-936.

Among 605 neonates with AKI, 13% had documented AKI. Those with documented AKI were more likely to have severe AKI (70.5% vs. 51%, p < 0.001) and SCr-only AKI (76.9% vs. 50.1%, p = 0.04). Nephrology consultation mediated 78.0% (95% CL 46.5-109.4%) of the total effect of AKI severity and 82.8% (95% CL 70.3-95.3%) of the total effect of AKI diagnostic criteria on documentation.

doi: 10.1038/s41372-022-01424-3

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Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study

April 18, 2022

Marissa Janel Defreitas, Russell Griffin, Keia Sanderson, Arwa Nada, Jennifer R Charlton, Jennifer Jetton, Alison Kent, Ronnie Guillet, David Askenazi , C Abitbol. Am J Perinatol. 2022 Feb 23.

Neonates exposed to any maternal HTN disorder had a tendency towards less overall and early AKI. When stratified by inborn versus outborn, exposure to both maternal HTN disorders was associated with a significantly reduced odds of early AKI only in the inborn neonates. Exposure to maternal HTN, especially pre/eclampsia superimposed on chronic HTN, was associated with less likelihood of early AKI in the inborn group.

doi: 10.1055/a-1780-2249 [..] read more

Correction to: Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group.

March 16, 2022

Nada A, Askenazi D, Kupferman JC, Mhanna M, Mahan JD, Boohaker L, Li L, Griffin RL; AWAKEN Collaborative. Pediatr Nephrol. 2022 Jul;37(7):1699-1700.

Erratum for "Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group" doi: 10.1007/s00467-021-05295-2. Epub 2021 Oct 18. PMID: 34657971

doi: 10.1007/s00467-022-05495-4

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