Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial
December 29, 2022- Michelle C Starr, Russell Griffin, Katja M Gist, Jeffrey L Segar, Rupesh Raina, Ronnie Guillet, Saudamini Nesargi, Shina Menon, Nekayla Anderson, David J Askenazi, David T Selewski; Neonatal Kidney Collaborative Research Committee. JAMA Netw Open. 2022 Dec 1;5(12):e2248826.
- A total of 874 neonates (449 [51.4%] male; mean [SD] BW, 801 [188] g; 187 [21.4%] Hispanic, 676 [77.3%] non-Hispanic, and 11 [1.3%] of unknown ethnicity; 226 [25.9%] Black, 569 [65.1%] White, 51 [5.8%] of other race, and 28 [3.2%] of unknown race) were included in this analysis. Of these 874 neonates, 458 (52.4%) received mechanical ventilation on postnatal day 14, and 291 (33.3%) had severe BPD or had died. Median peak positive FB was 11% (IQR, 4%-20%), occurring on postnatal day 13 (IQR, 9-14). A total of 93 (10.6%) never decreased below their BW.
- doi: 10.1001/jamanetworkopen.2022.48826