• Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial
    • Michelle C Starr, Russell Griffin, Katja M Gist, Jeffrey L Segar, Rupesh Raina, Ronnie Guillet, Saudamini Nesargi, Shina Menon, Nekayla Anderson, David J Askenazi, David T Selewski; Neonatal Kidney Collaborative Research Committee. JAMA Netw Open. 2022 Dec 1;5(12):e2248826.
    • A total of 874 neonates (449 [51.4%] male; mean [SD] BW, 801 [188] g; 187 [21.4%] Hispanic, 676 [77.3%] non-Hispanic, and 11 [1.3%] of unknown ethnicity; 226 [25.9%] Black, 569 [65.1%] White, 51 [5.8%] of other race, and 28 [3.2%] of unknown race) were included in this analysis. Of these 874 neonates, 458 (52.4%) received mechanical ventilation on postnatal day 14, and 291 (33.3%) had severe BPD or had died. Median peak positive FB was 11% (IQR, 4%-20%), occurring on postnatal day 13 (IQR, 9-14). A total of 93 (10.6%) never decreased below their BW.
    • doi: 10.1001/jamanetworkopen.2022.48826
  • Correction to: Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group. 
    • Nada A, Askenazi D, Kupferman JC, Mhanna M, Mahan JD, Boohaker L, Li L, Griffin RL; AWAKEN Collaborative. Pediatr Nephrol. 2022 Jul;37(7):1699-1700.
    • Erratum for "Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group" doi: 10.1007/s00467-021-05295-2. Epub 2021 Oct 18. PMID: 34657971
    • doi: 10.1007/s00467-022-05495-4
  • Documentation of acute kidney injury at discharge from the neonatal intensive care unit and role of nephrology consultation.
    • Chmielewski J, Chaudhry PM, Harer MW, Menon S, South AM, Chappell A, Griffin R, Askenazi D, Jetton J, Starr MC; Neonatal Kidney Collaborative. J Perinatol. 2022 Jul;42(7):930-936.
    • Among 605 neonates with AKI, 13% had documented AKI. Those with documented AKI were more likely to have severe AKI (70.5% vs. 51%, p < 0.001) and SCr-only AKI (76.9% vs. 50.1%, p = 0.04). Nephrology consultation mediated 78.0% (95% CL 46.5-109.4%) of the total effect of AKI severity and 82.8% (95% CL 70.3-95.3%) of the total effect of AKI diagnostic criteria on documentation.
    • doi: 10.1038/s41372-022-01424-3
  • Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study
    • Marissa Janel Defreitas, Russell Griffin, Keia Sanderson, Arwa Nada, Jennifer R Charlton, Jennifer Jetton, Alison Kent, Ronnie Guillet, David Askenazi , C Abitbol. Am J Perinatol. 2022 Feb 23.
    • Neonates exposed to any maternal HTN disorder had a tendency towards less overall and early AKI. When stratified by inborn versus outborn, exposure to both maternal HTN disorders was associated with a significantly reduced odds of early AKI only in the inborn neonates. Exposure to maternal HTN, especially pre/eclampsia superimposed on chronic HTN, was associated with less likelihood of early AKI in the inborn group.
    • doi: 10.1055/a-1780-2249