Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study
November 13, 2021- Abby M Basalely, Russell Griffin, Katja M Gist, Ronnie Guillet, David J Askenazi, Jennifer R Charlton, David T Selewski, Mamta Fuloria, Frederick J Kaskel Kimberly J Reidy, AWAKEN Study Group. Journal of Perinatology. 2021
- Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated with hyponatremia (HR 2.15, 95% CI 1.07-4.31), hypernatremia (HR 4.23, 95% CI 2.07-8.65), and combined hypo/hypernatremia (HR 6.39, 95% CI 2.01-14.01). In stratified models by AKI-status, hypernatremia and hypo/hypernatremia increased risk of mortality in neonates without AKI.
- doi: 10.1038/s41372-021-01260-x