Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group

October 18, 2021

  • Arwa Nada, David Askenazi, Juan C Kupferman, Maroun Mhanna, John D Mahan, Louis Boohaker, Linzi Li, Russell L Griffin. Pediatr Nephrol. 2021 Oct 18.
  • Low albumin levels were associated with increased odds of neonatal AKI; for every 0.1 g/dL decrease in albumin, the odds of late AKI increased by 12% on continuous analysis. After adjustment for potential confounders, neonates with albumin values in the lowest quartiles (< 2.2 g/dL) had an increased odds of early [Adjusted Odd Ratio (AdjOR) 2.5, 95% CI = 1.1-5.3, p < 0.03] and late AKI [AdjOR 13.4, 95% CI = 3.6-49.9, p < 0.0001] compared to those with albumin in the highest quartile (> 3.1 g/dL). Albumin levels of 2.6 g/dL and 2.4 g/dL best predicted early (AUC = 0.59) and late AKI (AUC = 0.64), respectively.
  • doi: 10.1007/s00467-021-05295-2