• AWAKEN-Ing a New Frontier in Neonatal Nephrology
    • David Joseph Askenazi. Front Pediatr. 2020 Feb 7;8:21.
    • In 2013, literature about the epidemiology of neonatal acute kidney injury (AKI) was limited to primarily retrospective, single center studies that suggested that AKI was common and that those with AKI had higher rates of mortality. We developed a 24-center retrospective cohort of neonates admitted to the NICU between January 1 and March 31, 2014. Analysis of the Assessment of Worldwide Acute Kidney Epidemiology in Neonates (AWAKEN) cohort, has allowed us to describe the prevalence, risk factors and impact of neonatal AKI for different gestational age cohorts.
    • doi: 10.3389/fped.2020.00021
  • Low Hemoglobin Levels Are Independently Associated With Neonatal Acute Kidney Injury: A Report From the AWAKEN Study Group
    • Arwa Nada, David Askenazi, Louis J Boohaker, Linzi Li, John D Mahan, Jennifer Charlton, Russell L Griffin, AWAKEN Study Group. Pediatric Research (2020)
    • Lower Hb in the first postnatal week was associated with late AKI, though the association no longer remained after fluid balance was included. Minimum Hb in the first postnatal week was significantly lower in neonates with AKI after the first postnatal week (late AKI). After controlling for multiple potential confounders, compared to neonates with a minimum Hb ≥17.0 g/dL, both those with minimum Hb ≤12.6 and 12.7-14.8 g/dL had an adjusted increased odds of late AKI (aOR 3.16, 95% CI 1.44-6.96, p = 0.04) and (aOR 2.03, 95% CI 1.05-3.93; p = 0.04), respectively. This association was no longer evident after controlling for fluid balance. The ability of minimum Hb to predict late AKI was moderate (c-statistic 0.68, 95% CI 0.64-0.72) with a sensitivity of 65.9%, a specificity of 69.7%, and a PPV of 20.8%.
    • doi: 10.1038/s41390-020-0963-x