Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection
October 11, 2024Henry A Zapata, Namrata Todurkar, Kristen Favel, Russell L Griffin, Michelle C Starr, Jennifer R Charlton, Ryan M McAdams, David Askenazi, Tapas Kulkarni, Shina Menon, Cherry Mammen, Matthew W Harer. J Perinatol. 2024 Oct 11.
The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold increased adjusted odds of estimated glomerular filtration rate (eGFR) <90 mL/min/1.73m2. No significant associations were noted between DCC and albuminuria or elevated blood pressure.
doi: 10.1038/s41372-024-02143-7
[..] read more
Correction: Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm
July 19, 2024Keia Sanderson, Russell Griffin, Nekayla Anderson, Andrew M South, Jonathan R Swanson, Michael Zappitelli, Heidi J Steflik, Marissa J DeFreitas, Jennifer Charlton, David Askenazi; Neonatal Kidney Collaborative (NKC) Research Committee. Pediatr Res. 2024 Jul 19.
Erratum for "Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm."
doi: 10.1038/s41390-024-03221-4
[..] read more
Advocating for the inclusion of kidney health outcomes in neonatal research: best practice recommendations by the Neonatal Kidney Collaborative
July 5, 2024Kimberly J Reidy, Ronnie Guillet, David T Selewski, Marissa Defreitas, Sadie Stone, Michelle C Starr, Matthew W Harer, Namrata Todurkar, Kim T Vuong, Semsa Gogcu, David Askenazi, Trent E Tipple, Jennifer R Charlton. J Perinatol. 2024 Jul 5.
Acute kidney injury (AKI) occurs in nearly 30% of sick neonates. Chronic kidney disease (CKD) can be detected in certain populations of sick neonates as early as 2 years. AKI is often part of a multisystem syndrome that negatively impacts developing organs resulting in short- and long-term pulmonary, neurodevelopmental, and cardiovascular morbidities.
doi: 10.1038/s41372-024-02030-1
[..] read more
Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm
March 4, 2024Keia Sanderson, Russell Griffin, Nekayla Anderson, Andrew M South, Jonathan R Swanson, Michael Zappitelli, Heidi J Steflik, Marissa J DeFreitas, Jennifer Charlton, David Askenazi; Neonatal Kidney Collaborative (NKC) Research Committee
Of 923 participants, 2% had early severe AKI. In the adjusted model, gestational diabetes (adjusted HR (aHR) 5.4, 95% CI 1.1-25.8), non-steroidal anti-inflammatory drugs (NSAIDs) (aHR 3.2, 95% CI 1.0-9.8), and vancomycin (aHR 13.9, 95% CI 2.3-45.1) were associated with early severe AKI. Late severe AKI occurred in 22% of participants. Early severe AKI (aHR 2.5, 95% CI 1.1-5.4), sepsis (aHR 2.5, 95% CI 1.4-4.4), vasopressors (aHR 2.9, 95% CI 1.8-4.6), and diuretics (aHR 2.6, 95% CI 1.9-3.6) were associated with late severe AKI. Participants who had necrotizing enterocolitis or received NSAIDs had longer severe AKI duration.
doi: 10.1038/s41390-024-03102-w
[..] read more
Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study
February 8, 2024Austin D Rutledge, Russell L Griffin, Katherine Vincent, David J Askenazi, Jeffrey L Segar, Juan C Kupferman, Shantanu Rastogi, David T Selewski, Heidi J Steflik; Neonatal Kidney Collaborative. JAMA Netw Open 2024 Feb 5;7(2):e2355307.
The study cohort (n = 2162) included 1233 male neonates (57.0%). Gestational age distribution was less than 29 weeks for 276 neonates (12.8%), 29 to less than 36 weeks for 958 (44.3%), and 36 weeks or older for 928 (42.9%). Of 605 neonates with AKI, 133 (22.0%) developed rAKI with risk factors including younger gestational age, lower birthweight, and higher stage of initial AKI. Infants with rAKI experienced longer median LOS (no AKI, 17 [IQR, 8-34] days; sAKI, 18 [IQR, 9-45] days; rAKI, 60 [IQR, 25-109] days; P < .001). Time-varying Cox proportional hazards regression models suggest rAKI is independently associated with a lower hazard of discharge (adjusted hazard ratio, 0.7 [95% CI, 0.6-0.9]; P = .01) when compared with sAKI, but [..] read more